Dr. Joseph Stanford reviews the recent study looking at the theoretical population-level impact of expanding Restorative Reproductive Medicine (RRM) among subfertile couples in the United States. The discussion covered demographic context, study methodology, simulation results, workforce challenges, and policy implications. ...

Hviid KVR, Banasik K, Mortensen LH, et al. Periconceptional GLP-1 receptor agonist exposure and obstetric outcomes: a Danish nationwide cohort study. Hum Reprod Open. 2026;2026(2):hoag015. Published 2026 Mar 18. doi:10.1093/hropen/hoag015 ...

This two-part CME activity reviews reproductive physiology through the lens of the ovarian continuum. Presented by Craig Turczynski, PhD, this foundational course explores normal cycle variation, ovulation as a sign of health, ovarian activity across the reproductive lifespan, and how chart observations may help distinguish normal variants from possible health concerns. ...

Raul Sanchez Gutierres, MD, PhD explores the impact of male genital tract infections on sperm function, with a focus on prevention, microbiological evaluation in non-fertile men, and emerging methods for detecting infection in seminal fluid ...

Dr. Pilar Vigil explores the relationship between stress, the menstrual cycle, and ovulatory dysfunction. Participants will learn how stress may affect regular ovulation, how ovulatory dysfunction can be identified, and how ovulation can be understood as an important sign of health in clinical practice ...

Maria Wolfs, MD, MHSc, reviews the diagnosis and metabolic implications of PMOS (formerly PCOS), with a focus on insulin resistance. Participants will learn how to screen for insulin resistance, recognize its clinical consequences, and consider management options relevant to reproductive and metabolic health ...

Presented by Dr. Jerome Check, this presentation discusses inducing ovulation and achieving successful pregnancies in women seemingly in total menopause, highlighting methods to enhance follicle sensitivity to FSH, with compounded ethinyl estradiol being the cost-effective approach. It emphasizes the importance of supplemental progesterone, particularly vaginally, to maximize pregnancy success post-ovulation induction. ...

This Grand Rounds presentation by Anne Marie Z. Jukic, Ph.D., explores the role of vitamin D in women’s reproductive health, including vitamin D metabolism, menstrual cycle function, fertility, time to pregnancy, ovarian reserve, and inflammation. The session reviews evidence from animal and human studies and considers potential biological pathways linking vitamin D status with reproductive health outcomes ...

“The impact of adenomyosis localization in myometrium on fertility and pregnancy outcomes: a narrative systematic review of the literature” Georgios Kolovos, Theodoros Kalampokas, Ioannis Dedes, Nikolaos Vlahos, Michael Mueller. Front Reprod Health 2026 Mar 16, Presented in Spanish by Dra. María del Rosario Zavala Guzmán, Obstetrics and Gynecology Resident, Universidad de los Andes, Chile, with English dubbing and closed captions available ...

A new postgraduate training program in restorative reproductive medicine is launching. Explore courses, career pathways, and opportunities to register your interest, contribute feedback, and download the program guide ...

Liu Y, Zhao Z, Jiang X, You X, Qu D. Doxycycline vs levofloxacin combined with tinidazole for treating chronic endometritis: a randomized controlled trial. Am J Obstet Gynecol. 2026. Presented in Spanish by Dr. Juan González de Canales, with English closed captions available ...

Chronopoulou E, Gaetano-Gil A, Shaikh S, et al. Optimizing intrauterine insemination: A systematic review and meta-analysis of the effectiveness and safety of clinical treatment add-ons. Acta Obstet Gynecol Scand. 2024;103(10):1919-1932. doi:10.1111/aogs.14858 ...

Dr. José Ignacio Sánchez Méndez presents a five-year study evaluating the live birth rate in 1,310 couples treated with NPT with infertility treated at the Fertilitas medical centre in Spain. ...

IIRRM Journal Club: First-line surgery vs first-line ART to manage infertility in women with deep endometriosis without bowel involvement: A multi-centric propensity-score matching comparison. C. Ferrier a et. al. European Journal of Obstetrics and Gynecology 280 (2023) 184–190 https://doi.org/10.1016/j.ejogrb.2022.11.013 ...

This lecture focusses on Premature Ovarian Insufficiency (POI), its diagnosis, health implications, and RRM treatment approaches available. POI is defined as impaired ovarian function before age 40 and affects 1 in 100 women under 40 and 1 in 1,000 women under 30. Dr. Whittaker covers diagnostic criteria, risk factors, health implications, and various treatment approaches including hormone therapy, DHEA supplementation, and emerging treatments like photobiomodulation and platelet-rich plasma (PRP) ...

Presented by: Dra. Catalina Cruz Castro: "Prevalence of dysmorphic uterus in infertile women by 3D-TVUS: a retrospective longitudinal cohort study". Vichinsartvichai P, Lertlerphant S, Ratchanon S. Reprod Biol Endocrinol. 2025 Oct 27;23(1):137 ...

This practice survey evaluated 2019 data retrospectively from a clinic practicing restorative reproductive medicine (RRM) for live birth, multiple pregnancy, prematurity, and low birth weight and subsequently benchmarked this against IVF statistics published for 2019 from the UK and US. ...

Presented by Lynnette Sievert, PhD, this webinar explores the biology of menopause, highlighting that it is more than simply the end of fertility. Participants will examine variation and heritability in age at menopause and consider how an evolutionary perspective can inform clinical care and counselling ...

"The additional value of ultrasound markers in the diagnosis of polycystic ovary syndrome". Barbagallo F, van Schilfgaarde E, Lujan ME, Laven JSE, Louwers YV.  Fertil Steril. 2025. Presented by: Dra. Tania Errasti. ...

Presented by: Dra Dominga Ferrari Sande, "Optimal lead follicle size for human chorionic gonadotropin trigger in clomiphene citrate and intrauterine insemination cycles: an analysis of 1,676 treatment cycles" . Hancock KL, Pereira N, Christos PJ, Petrini AC, Hughes J, Chung PH, Rosenwaks Z. Fertil Steril. 2021 Apr;115(4):984-990. doi: 10.1016/j.fertnstert.2020.10.026. Epub 2020 Dec 4. PMID: 33272641 ...

Dr. Mary Davenport presents on folate and folic acid. Learn about the role of MTHFR genetic variants, clinical supplementation guidelines, and the impact of folate on reproductive health and patient care. ...

This study from Bernot G, Lallemand L, Le Menager C, and Ecochard R. presents the work of 66 instructors and 15 doctors to help 551 couples conceive, 37% of whom conceived during the study, and reinforces the role of fertility instructors as part of the multi-disciplinary care team. ...

April 2025 NeoFertility Case Reviews with Dr. Phil Boyle ...

Riemma G, Parry JP, De Franciscis P, et al. Hysteroscopic criteria for the diagnosis of chronic endometritis: a systematic review and diagnostic test accuracy meta-analysis. Am J Obstet Gynecol. Published online March 10, 2025. doi:10.1016/j.ajog.2025.03.005 ...

Dr. Nick Kongoasa presents a sustainable and replicable clinical model for Restorative Reproductive Medicine (RRM), highlighting the role of advanced practitioners in leading care, and innovative approaches to RRM education, research, and collaborative partnerships that support the advancement of RRM practices ...

Presented by Bruce A Lessey MD, PhD, this activity explores the importance of synchrony between the embryo, progesterone, and endometrium in achieving successful implantation and pregnancy. Participants will review biomarkers of endometrial receptivity, diagnostic considerations for endometriosis, and treatment approaches relevant to infertility and recurrent miscarriage ...

Zhao P, Jungheim ES, Bedrick BS, et al. Sleep variability and time to achieving pregnancy: findings from a pilot cohort study of women desiring pregnancy. Fertil Steril. Published online January 24, 2025. doi:10.1016/j.fertnstert.2025.01.019 ...

Fernandez H, Miquel L, Sroussi J, et al. Effectiveness of degradable polymer film in the management of severe or moderate intrauterine adhesions (PREG-2): a randomized, double-blind, multicenter, stratified, superiority trial. Fertil Steril. 2024;122(6):1124-1133. doi:10.1016/j.fertnstert.2024.07.020 ...

Dr. Christian Gnoth presents an in-depth exploration of the evaluation and application of luteinizing hormone (LH), human chorionic gonadotropin (hCG), and uterine natural killer (uNK) cells throughout the ovarian cycle. This talk will highlight the hormonal dynamics that influence fertility and pregnancy, as well as the role of hCG in modulating uNK cell populations in the uterus ...

Mulligan CJ, Quinn EB, Hamadmad D, et al. Epigenetic signatures of intergenerational exposure to violence in three generations of Syrian refugees. Sci Rep. 2025;15(1):5945. Published 2025 Feb 27. doi:10.1038/s41598-025-89818-z ...

Members and those who are enrolled in, or completed advanced training with NeoFertility get immediate access to all past NeoFertility medical case reviews. To join upcoming live medical case reviews consult the schedule here. Click "case review" below to begin the presentation. Disclosures: Faculty: Dr. Phil Boyle is the founder and ...

La Dra. Tania Errasti, de CUN, presentará un análisis crítico del artículo: Santoro N, Polotsky AJ. Infertility Evaluation and Treatment. N Engl J Med. 2025 Mar ...

Article: Ran S Rotem, Marc G Weisskopf, Brian Bateman, Krista Huybrechts, Sonia Hernández-Diáz, Maternal periconception hyperglycemia, preconception diabetes, and risk of major congenital malformations in offspring, Human Reproduction, Volume 39, Issue 12, December 2024, Pages 2816–2829, https://doi.org/10.1093/humrep/deae233 ...

ESHRE, ASRM, CREWHIRL and IMS Guideline Group on POI, Panay, N., Anderson, R. A., Bennie, A., Cedars, M., Davies, M., Ee, C., Gravholt, C. H., Kalantaridou, S., Kallen, A., Kim, K. Q., Misrahi, M., Mousa, A., Nappi, R. E., Rocca, W. A., Ruan, X., Teede, H., Vermeulen, N., Vogt, E., & Vincent, A. J. (2024). Evidence-based guideline: premature ovarian insufficiency†‡. Climacteric : the journal of the International Menopause Society, 27(6), 510–520. https://doi.org/10.1080/13697137.2024.2423213 ...

Xie L, Zhang D, Ma H, et al. The Effect of Berberine on Reproduction and Metabolism in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Control Trials. Evid Based Complement Alternat Med. 2019;2019:7918631. Published 2019 Dec 13. doi:10.1155/2019/7918631 ...

NeoFertility Medical case reviews. ...

S M Savukoski, H Silvén, P Pesonen, E Pukkala, M Gissler, E Suvanto, M -M Ollila, M Niinimäki, Excess of severe autoimmune diseases in women with premature ovarian insufficiency: a population-based study, Human Reproduction, Volume 39, Issue 11, November 2024, Pages 2601–2607, https://doi.org/10.1093/humrep/deae213 ...

Dr. Patrick Yeung Jr. presents updates on surgical management of Endometriosis and results of their new paper, a prospective cohort study aimed to evaluate the effectiveness of optimal excision surgery for endometriosis in reducing repeat surgery rates compared to historical data from ablation procedures, with the cohort of patients showing a notably low repeat surgery rate of 2.5% (15 out of 620 patients) following optimal excision, contrasting with suggested historical rates of 40-60% for ablation (Bozdağ 2015).  The team also looked at the relationship between hormonal suppression use before surgery and the stage of endometriosis, finding no significant correlation, suggesting that hormonal suppression may not prevent disease progression ...

Dr. Nugen will review data from his retrospective cohort study looking at outcomes of endometriosis surgery for infertility, suggesting that excisional surgery with MIGS training was more successful (higher rate of live births) than standard surgery that included ablation. He also reviews other literature and bleeding at excisional sites, and ...

NeoFertility Medical case reviews including a complex case of elevated FSH and low AMH. ...

Artículo: Sun, Yu et al. “Relationship between chronic endometritis and fallopian tube obstruction and its influence on pregnancy outcome after fallopian tubal recanalization.” Therapeutic advances in reproductive health vol. 18 26334941241308413. 25 Dec. 2024, doi:10.1177/26334941241308413 ...

Artículo: Huang Y, Kuang X, Jiangzhou H, Li M, Yang D, Lai D. Using anti-Müllerian hormone to predict premature ovarian insufficiency: a retrospective cross-sectional study. Frontiers in Endocrinology. 2024;15. doi:10.3389/fendo.2024.1454802 ...

Dr. Mark Noar presents background and research on the development and validation of new noninvasive testing for the diagnosis of endometriosis using GIMA biomarkers as well as the clinical applications of results ...

Article: Ruiqiong Zhou, Zhenghong Zhu, Mei Dong, Zhaoyi Wang, Li Huang, Songlu Wang, Xiqian Zhang, Fenghua Liu, Nonlinear correlation between serum vitamin D levels and the incidence of endometrial polyps in infertile women, Human Reproduction, 2024;, deae241, https://doi.org/10.1093/humrep/deae241 ...

Medical case reviews with Dr. Phil Boyle, NeoFertility. ...

Mingyang Li, Renyi Zhou, Daier Yu, Dan Chen, Aimin Zhao, A nomogram and risk stratification to predict subsequent pregnancy loss in patients with recurrent pregnancy loss, Human Reproduction, Volume 39, Issue 10, October 2024, Pages 2221–2232, https://doi.org/10.1093/humrep/deae181 ...

Explore the intricate hormonal dynamics of the early menstrual cycle and their impact on the timing of the fertile window. Published in Human Reproduction Journal in October 2024, René Écochard, MD, PhD, presents the team's research, "Early menstrual cycle impacts of oestrogen and progesterone on the timing of the fertile window" ...

Dr. Phil Boyle reviews the 2023 Royal College of Obstetricians and Gynaecologists guidelines for recurrent miscarriage and discusses how these guidelines compare with RRM approaches. An RRM-managed patient case report is reviewed. What guidelines would be changed or added in the development of RRM clinical practice guidelines compared with these or other practice guidelines for recurrent miscarriage? ...