This lecture focusses on Premature Ovarian Insufficiency (POI), its diagnosis, health implications, and RRM treatment approaches available. POI is defined as impaired ovarian function before age 40 and affects 1 in 100 women under 40 and 1 in 1,000 women under 30. Dr. Whittaker covers diagnostic criteria, risk factors, health implications, and various treatment approaches including hormone therapy, DHEA supplementation, and emerging treatments like photobiomodulation and platelet-rich plasma (PRP).