2025 International Clinical & Scientific Congress for Restorative Reproductive Medicine

Join us in person or virtually on September 24-27 2025.

Learn More & Register!

What is RRM?

Restorative reproductive medicine (RRM) corrects underlying causes and contributors to infertility and reproductive dysfunction.

"What's wrong?"

RRM focuses on this question, then restores or optimizes natural function without suppressing or bypassing the problem.

Cycle or Fertility Charting

Fertility or cycle charts are an important tool to carefully time tests and medications in women; changes in the chart empower her to know her body and the effects of treatments.

Restorative Andrology

A branch of RRM focusing on male reproductive health. The goal is the same: identify and treat underlying abnormalities, restore health, and improve reproductive function and fertility.

RRM is not one charting method

All believe in empowering the patient with scientifically sound and well researched knowledge about their fertility.

Education

The International Institute for Restorative Reproductive Medicine offers unparalleled opportunities for continuing education and professional development.

Together.

Transforming Reproductive Medicine.

Join Us

Together. Transforming Reproductive Medicine.

The International Institute for Restorative Reproductive Medicine is the leading voice in uniting providers and researchers who share a common belief that patients deserve scientifically-based and well researched reproductive health care services that cooperate with and restore reproductive function. To address reproductive health problems, restorative reproductive medicine (RRM) exclusively focuses investigations and treatments on identifying and correcting abnormalities, restoring or optimizing normal reproductive function.

Membership

Becoming a member of the International Institute for RRM allows you to join a growing network of professionals and supporters who are helping transform reproductive medicine. As a member, you take an active role in shaping a future in which restorative reproductive medicine, backed by quality research and years of experience, becomes the standard of care in reproductive health services.

Join us

Upcoming Events & Webinars

Upcoming continuing medical education and case discussions for IIRRM members. To view all upcoming webinars and register click here.

Oct 09, 2025

IIRRM Journal Club (Español)

IIRRM Journal Club es un evento mensual en línea, celebrado para la revisión y evaluación crítica de la investigación publicada relevante para el campo de la Medicina Reproductiva Restaurativa (RRM).[...]

Oct 14, 2025

Research Update: RRM outcomes compared to IVF for the treatment of infertility: a retrospective evaluation of a 2019 clinic cohort compared to one cycle of IVF

This practice survey evaluated 2019 data retrospectively from a clinic practicing Restorative Reproductive Medicine (RRM) for live birth, multiple pregnancy, prematurity, and low birth weight and subsequently benchmarked this against[...]

Oct 21, 2025

Journal Club (in Ukrainian)

Ukrainian Journal Club is held online on the third Tuesday of each month, to review and provide a critical evaluation of published research relevant to the field of Restorative Reproductive[...]

Oct 30, 2025

Grand Rounds: The clinical implications of an evolutionary perspective on menopause

Lynnette Leidy Sievert, PhD, presents on the clinical implications of an evolutionary perspective on menopause.

Nov 03, 2025

RRM Case Discussions: Explore the FACTS

This monthly case-based discussion brings together clinicians, researchers, teachers and other allied health providers practising or interested in Restorative Reproductive Medicine (RRM). Prepare and present a case, discuss your diagnostic[...]

Nov 13, 2025

IIRRM Journal Club (Español)

Nov 18, 2025

Journal Club (in Ukrainian)

Ukrainian Journal Club is held online on the third Tuesday of each month, to review and provide a critical evaluation of published research relevant to the field of Restorative Reproductive[...]

Nov 27, 2025

IIRRM Grand Rounds

Hosted online monthly, IIRRM Grand Rounds aims to enhance the efficiency, effectiveness, and quality of healthcare delivery and encourage collaboration between disciplines and providers. A different speaker is invited each[...]

Dec 01, 2025

Consult the IIRRM: RRM Case Discussions

June RRM Case Discussions with IIRRM. Prepare and present a case, discuss your diagnostic and therapeutic challenges among members of the RRM community, or just listen, meet and make new[...]

Latest News

Congressional Briefing: The Progress and Promise of Restorative Reproductive Medicine

18 September 2025

With infertility rates climbing in the United States, medical experts from the International Institute for Restorative Reproductive Medicine (IIRRM) will give a congressional briefing to highlight restorative reproductive medicine (RRM) as an important, cost-effective treatment option that benefits patients and public health. This growing medical discipline focuses on diagnosing and treating underlying causes of infertility, offering couples a path to natural conception by optimizing reproductive health. While IVF may be the only answer for a small subset of patients, most couples with infertility have underlying causes that are identifiable and treatable.

Learn More

The Progress and Promise of Restorative Reproductive Medicine

18 July 2025

In the statement “The Progress and Promise of Restorative Reproductive Medicine” the IIRRM responds to recent statements by ACOG and ASRM that contain misrepresentations about restorative reproductive medicine. We have provided a detailed response to each inaccurate statement.

Learn More

Announcement of New Journal for Restorative Reproductive Medicine and Call for Submission of Papers

2 February 2025

JRRM is a peer-reviewed, open-access medical journal for clinicians, scientists, professionals, and patients. Our vision is that JRRM will disseminate and promote evidence-based information to support and restore human fertility and reproductive health.

Learn More

The Surveillance of Treatment Outcomes in Restorative Reproductive Medicine (STORRM)

27 January 2025

The STORRM project is underway! Register your interest and download the resources to contribute as an individual clinician or as a clinic in this project. The goal is to establish an ongoing, self-sustaining, international registry for restorative reproductive medicine (RRM) treatments for subfertility and miscarriage, and determine the outcomes of treatment.

Learn More

Folate: Controversies and Update

Dr. Mary Davenport presents on folate and folic acid. Learn about the role of MTHFR genetic variants, clinical supplementation guidelines, and the impact of folate on reproductive health and patient care.

Access Activity

This study presents the work of 66 instructors and 15 doctors to help 551 couples conceive, 37% of whom conceived during the study, and reinforces the role of fertility instructors as part of the multi-disciplinary care team. Highlights: Use the woman’s menstrual cycle chart in the infertility management process. Train primary care physicians to participate in the infertility management process. Engaging Fertility Instructors to provide therapeutic education to infertile women. Article: Bernot G, Lallemand L, Le Menager C, Ecochard R. Participation of general practitioners and therapeutic patient education in the care of infertile couples

Participation of general practitioners and therapeutic patient education in the care of infertile couples

This study from Bernot G, Lallemand L, Le Menager C, and Ecochard R. presents the work of 66 instructors and 15 doctors to help 551 couples conceive, 37% of whom conceived during the study, and reinforces the role of fertility instructors as part of the multi-disciplinary care team.

Access Activity

A Focused Practice in Restorative Reproductive Medicine

Dr. Nick Kongoasa presents a sustainable and replicable clinical model for Restorative Reproductive Medicine (RRM), highlighting the role of advanced practitioners in leading care, and innovative approaches to RRM education, research, and collaborative partnerships that support the advancement of RRM practices.

Access Activity

Ovulation and Implantation: concert of hormones and cells

Dr. Christian Gnoth presents an in-depth exploration of the evaluation and application of luteinizing hormone (LH), human chorionic gonadotropin (hCG), and uterine natural killer (uNK) cells throughout the ovarian cycle. This talk will highlight the hormonal dynamics that influence fertility and pregnancy, as well as the role of hCG in modulating uNK cell populations in the uterus.

Access Activity

Research Updates: Surgical Management of Endometriosis

Dr. Patrick Yeung Jr. presents updates on surgical management of Endometriosis and results of their new paper, a prospective cohort study aimed to evaluate the effectiveness of optimal excision surgery for endometriosis in reducing repeat surgery rates compared to historical data from ablation procedures, with the cohort of patients showing a notably low repeat surgery rate of 2.5% (15 out of 620 patients) following optimal excision, contrasting with suggested historical rates of 40-60% for ablation (Bozdağ 2015). The team also looked at the relationship between hormonal suppression use before surgery and the stage of endometriosis, finding no significant correlation, suggesting that hormonal suppression may not prevent disease progression.

Access Activity

Factors Associated with Spontaneous Conception Leading to Live Birth in Infertility Patients

Dr. Nugen will review data from his retrospective cohort study looking at outcomes of endometriosis surgery for infertility, suggesting that excisional surgery with MIGS training was more successful (higher rate of live births) than standard surgery that included ablation. He also reviews other literature and bleeding at excisional sites, and adhesion formation. Learning Outcomes: Faculty Disclosure: None declared. Please log in below - or join IIRRM to access live and self-paced free CME as well as other member benefits. For support or questions please contact info@iirrm.org. Username Password Remember Me Forgot Password

Access Activity

Early Menstrual cycle impacts of oestrogen & progesterone on the timing of the fertile window

The Latency Phase of the Menstrual Cycle Deserves More Attention

Explore the intricate hormonal dynamics of the early menstrual cycle and their impact on the timing of the fertile window. Published in Human Reproduction Journal in October 2024, René Écochard, MD, PhD, presents the team's research, "Early menstrual cycle impacts of oestrogen and progesterone on the timing of the fertile window"

Access Activity

Recurrent Miscarriage and Restorative Reproductive Medicine: RCOG Guidelines, RRM Insights, and Case Analysis

Dr. Phil Boyle reviews the 2023 Royal College of Obstetricians and Gynaecologists guidelines for recurrent miscarriage and discusses how these guidelines compare with RRM approaches. An RRM-managed patient case report is reviewed. What guidelines would be changed or added in the development of RRM clinical practice guidelines compared with these or other practice guidelines for recurrent miscarriage?

Access Activity

Utilizing at-home fertility monitoring with RRM in a case of infertility

This session will introduce how home urine hormone metabolite testing may correlate with traditional serum testing, noting more research is needed. Dr. Kimberly Barrows reviews a case report and discusses who to integrate this technology as part of an RRM workup for infertility for application to clinical care. Additionally, discover resources to integrate at-home monitoring into your practice or support patients already using this platform.

Access Activity

Histamine Intolerance Management and Myo-Inositol: A Novel Approach in RRM

Based on clinical experience, Dr. Victoria Mena provides a practical and simple guide to identify, diagnose, and treat excess histamine, and suggests wider use of myo-inositol in non-PCOS patients—especially in combination with diamine-oxidase—as a novel approach for those with histamine intolerance.

Background:Histamine is a mediator of multiple functions in the body. Histamine intolerance is a condition that disturbs up to 1/5 to 1/3 of patients, with different symptoms and a potential dis-regulation of cortisol, but it is usually overlooked. Myo-inositol is used frequently in patients with PCOS, with clear effects on hormonal regulation and cycle balancing, but it is not used in other groups of patients with infertility or cycle defects.

Access Activity

Sperm DNA Integrity and Male Health

Since 1992 Dr. Preben Christensen has been researching sperm quality and reduced fertility, which in 2006 led to the founding of SPZ Lab - which offers an examination of sperm cell DNA integrity (SDI-testing) and offers testing to many European fertility clinics and childless couples. As a result of his diagnostic work, he has developed a keen research interest in exploring male fertility as a marker for a man’s general health with reduced fertility increasing the likelihood of the man developing future diseases as well as having possible negative implications for the health of any future children.

Access Activity

Investigating Endometriosis and PCOS as Diametric Conditions

This webinar explores the concept that endometriosis and PCOS represent opposite outcomes of variation in HPG axis development, with endometriosis linked to low prenatal and postnatal testosterone, while PCOS is associated with high prenatal testosterone. Endometriosis and PCOS could be considered as reflecting maladaptive extremes of female fitness-related adaptations, which has direct implications for therapy and fertility restoration in women with endometriosis or PCOS. Involved in a number of research areas, Prof. Crespi also studies the evolutionary biology of risks for endometriosis and PCOS, from fetal programming to life histories. Credit Statement: The AAFP has reviewed Investigating Endometriosis and PCOS as Diametric Conditions and deemed it acceptable for up to 1.5 Enduring Materials, Self-Study AAFP Prescribed credit. Term of Approval is from 1/12/2023 to 1/12/2024. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Access Activity

Low Dose Naltrexone (LDN) and RRM

Dr. Phil Boyle who has used low-dose naltrexone (LDN) in his practice for over 20 years, runs through the history of naltrexone, its mechanism of action, clinical indications of use, and application to reproductive medicine, including a number of complex case examples from which saw benefit from treatment with LDN.

Upon completion of this CME activity, you should be able to:

1. Summarize the history of naltrexone and low-dose naltrexone (LDN) 2. Describe the mechanism of action and clinical indications of LDN use (When should LDN be considered in my patient?) 3. Assess when LDN may be useful to consider in reproductive medicine 4. Evaluate potential adverse reactions and drug interactions before prescribing LDN Additional downloads and references are posted below the lesson discussed during this presentation.

Access Activity

DHEA Treatment for Recurrent Miscarriage: Case Report

This case presents a multi-factorial assessment and approach with DHEA treatment, of a couple who sought treatment with NeoFertility after years of "unexplained" infertility, and history of 1 live birth and 6 pregnancies.

Access Activity

RRM Journal Club

Journal Club is your chance to stay up to date in the latest RRM research and application to clinical practice. These sessions provide a critical appraisal of published research relevant to the field of restorative reproductive medicine. IIRRM runs separate monthly Journal Clubs Meetings in English, Spanish, Ukrainian. Recent recordings and articles are listed for members to review below.

Journal Club (in Spanish): Hysteroscopic criteria for the diagnosis of chronic endometritis: a systematic review and diagnostic test accuracy meta-analysis

12 June 2025

Riemma G, Parry JP, De Franciscis P, et al. Hysteroscopic criteria for the diagnosis of chronic endometritis: a systematic review and diagnostic test accuracy meta-analysis. Am J Obstet Gynecol. Published online March 10, 2025. doi:10.1016/j.ajog.2025.03.005

Access Activity

Journal Club (in Ukrainian): Sleep variability and time to achieving pregnancy: findings from a pilot cohort study of women desiring pregnancy

21 May 2025

Zhao P, Jungheim ES, Bedrick BS, et al. Sleep variability and time to achieving pregnancy: findings from a pilot cohort study of women desiring pregnancy. Fertil Steril. Published online January 24, 2025. doi:10.1016/j.fertnstert.2025.01.019

Access Activity

Journal Club (in Spanish): Effectiveness of degradable polymer film in the management of severe or moderate intrauterine adhesions (PREG-2): a randomized, double-blind, multicenter, stratified, superiority trial.

15 May 2025

Fernandez H, Miquel L, Sroussi J, et al. Effectiveness of degradable polymer film in the management of severe or moderate intrauterine adhesions (PREG-2): a randomized, double-blind, multicenter, stratified, superiority trial. Fertil Steril. 2024;122(6):1124-1133. doi:10.1016/j.fertnstert.2024.07.020

Access Activity

Journal Club (in Ukrainian): Epigenetic signatures of intergenerational exposure to violence in three generations of Syrian refugees

16 April 2025

Mulligan CJ, Quinn EB, Hamadmad D, et al. Epigenetic signatures of intergenerational exposure to violence in three generations of Syrian refugees. Sci Rep. 2025;15(1):5945. Published 2025 Feb 27. doi:10.1038/s41598-025-89818-z

Access Activity

Together. Transforming Reproductive Medicine.

Upcoming Events & Webinars

Latest News

Latest CPD in Restorative Reproductive Medicine

RRM Journal Club

Are You Looking for an RRM Clinician?