Frontiers in Reproductive Health  (March 2026– Italy)

Fertility awareness methods and waiting conduct in idiopathic infertility: a prospective observational study

• 97 couples; female age <40, mean age ~34
• 2 years median duration of infertility, 27.5% prior ART
• RRM arm: pregnancy rate 51.2% @ 12 months, age <34: 90.9% conception; age 35–39: 36.7%
• ART arm: pregnancy rate 17.8% per complete ART cycle; age <34: 30%; age 35–39: 17.4%
• No clear advantage of immediate ART vs 12 months RRM in study’s population

Frontiers in Reproductive Health  (November 2025– Spain)

Natural procreative technology (NaProTechnology) for infertility: take-home baby rate and clinical outcomes in a 5-year single-center cohort of 1,310 couples

• 1,310 couples;  mean female age 35
• 2 years median duration of infertility, 27.5% prior ART
• Idiopathic infertility accounted for <2% of cases after comprehensive NPT evaluation
• Adjusted cumulative take-home baby rate of 62.1% after a median duration of 10.9 months (crude rate 35.3%)

Journal of Restorative Reproductive Medicine (Sept 2025 – Ireland)

Restorative reproductive medicine (RRM) outcomes compared to in-vitro fertilization (IVF) for the treatment of infertility: a retrospective evaluation of a 2019 clinic cohort compared to one cycle of IVF

• 187 couples; mean female age: 33.6
• 2.7 years mean duration of infertility; 19% prior IVF 
• Live Birth Rate: 41% ; time to conception for live birth patients averaged 12 months

Therapeutic Advances in Reproductive Health (May 2025 – Review Article)

Revitalizing reproductive health: innovations and future frontiers in restorative medicine

• Systematic review; 145 included studies
• Many ART failures occur due to unaddressed uterine or systemic pathology
• Infertility is often multifactorial and correctable
• RRM: Live birth: ~40–60% Cost: $2–5K
• ART (per cycle): Live birth: ~30–40% Cost: $10–15K

European Journal of Obstetrics and Gynecology and Reproductive Biology (February 2025 – France)

Participation of general practitioners and therapeutic patient education in the care of infertile couples

• 551 subfertile couples; 2 years avg. time trying
• 37% conception rate during study
• actuarial (time-adjusted) estimates suggest ~40–60% may conceive within 1 year
• highlights involvement of fertility instructors and general practitioners in core care team

Andrology  (February 2025– Italy)

Impact of Comprehensive Andrological & Multidisciplinary Care on Natural Conception

• 1,014 couples;  919 couples eligible for treatment, 28.9% prior ART
• 3.1 years mean duration of infertility
• Average age: 33.4 (female); 37.7 (male)
• Idiopathic infertility reduced to 8%
• 23% isolated male factor, 87% had identifiable, treatable causes; 45% combined male + female
• Conception rate: 40.9% (n=919)

Human Reproduction (Aug 2022 – USA, Canada, UK, Poland)

International Natural Procreative Technology Evaluation and Surveillance of Treatment for Subfertility (iNEST): enrollment and methods

• 834 subfertile couples; aged 19–47
• Average age: 34.0
• 21.4% had prior IUI or IVF
• Conception rate: 57% among all couples

Human Fertility (Oct 2019 – Australia)

Stratification of fertility potential according to cervical mucus symptoms: achieving pregnancy in fertile and infertile couples

• 384 women; consecutive clinical cohort
• 28% aged >35 years
• 51% with infertility ≥12 months
• Adjusted cumulative conception: 62.5% at 24 months

medRxiv (Apr 2021 – Australia)

Pregnancy outcomes from a restorative infertility treatment model: a single centre case series

• 162 couples; average female age: 33.7
• 2.8 years prior mean time trying
• Adjusted cumulative live birth: 57.4% at 24 months

This article is not yet peer-reviewed.

Fides et Ratio Scientific Quarterly (October 2020 – Ukraine)

Restorative reproductive medicine for infertility and recurrent miscarriage in the outpatient gynaecological practice in Ukraine

• 282 couples; 3 years prior mean time trying
• Mean time to pregnancy was 8 months
• Adjusted cumulative conception: 77.7% @ 24 months
• Adjusted cumulative live birth: 73.6% @ 24 months

Frontiers in Medicine (July 2018 – Ireland)

Healthy Singleton Pregnancies From Restorative Reproductive Medicine (RRM) After Failed IVF

• 403 couples; average female age: 37.2
• 100% had prior IVF (avg. 2.1 attempts)
• 5.8 years prior mean time trying
• Adjusted cumulative live birth: 32.1% with 92% born at ≥37 weeks

Arch Gynecol Obstet (Feb 2017 – Germany)

Natural conception rates in subfertile couples following fertility awareness training

• 187 subfertile women; aged 21–47
• 3.5 years prior mean time trying
• Conception rate: 38% at 8 months (all); 56% at 8 months (trying 1–2 yrs)

Canadian Family Physician (May 2012 – Canada)

Natural procreative technology for infertility and recurrent miscarriage

• 108 couples; average female age: 35.4
• 8% prior IVF; 3.2 years prior mean time trying
• Adjusted cumulative conception: 73% @ 24 months
• Adjusted cumulative live birth: 66% @ 24 months

JABFM (Sept–Oct 2008 – Ireland)

Outcomes From Treatment of Infertility With Natural Procreative Technology in an Irish General Practice

• 1072 couples; average female age: 35.8
• 33% prior ART; 5.6 years prior mean time trying
• Adjusted cumulative conception: 64.8% @ 24 months
• Adjusted cumulative live birth: 52.8% @ 24 months

STORRM

Surveillance of Treatment Outcomes for Restorative Reproductive Medicine

STORRM is an international RRM research registry developed by the International Institute for Restorative Reproductive Medicine (IIRRM) in collaboration with the University of Utah School of Medicine.

BJOG (July 2016 – USA)

Fertility treatments and adverse perinatal outcomes in a population-based sampling of births in Florida, Maryland, and Utah: a cross-sectional study

• 21,803 women (weighted sample: 1,022,597 women)
• In singletons ART associated with:
  • Preterm birth: OR 3.28 (95% CI 1.74–6.20)
  • Low birth weight: OR 2.91 (95% CI 1.99–4.26)
• Conclusions: Preterm birth and low birthweight associated with fertility treatments are largely attributable to multiple gestation, but are also related to underlying subfertility.

BMC Reproductive Health (Mar 2022 – USA/Utah)

Fertility treatments and the risk of preterm birth among women with subfertility: a linked-data retrospective cohort study

• IVF: 4.24× higher risk of preterm birth
• IUI: 3.17× higher risk of preterm birth