RRM Teacher Series: Exploring the relationship between gut microbiome and PCO

Presented by: April Lind, MD.



Studies have shown an association between PCO and the gut microbiome.  This webinar will briefly review PCO, and what is "the microbiome"? Learners will gain an understanding of how the microbiome impacts health and disease, including the potential relationship with PCO, and be able to suggest ways to optimize outcomes for patients with PCO.

With a better understanding of the role of the microbiome and PCO,  what possible mechanisms for new treatment approaches could be developed in this direction?  Interested in discussing more or sharing new research on this topic?  Comment on this topic in our forum and subscribe to be notified of new posts from members on this topic.

Research and publications on this topic are coming out regularly.  For download below are three recommended articles for reading on this topic further:

  1.  Maryan G Rizk, Varykina G Thackray, Intersection of Polycystic Ovary Syndrome and the Gut Microbiome , Journal of the Endocrine Society, Volume 5, Issue 2, February 2021, bvaa177, https://doi.org/10.1210/jendso/bvaa177 
  2. Zhao X, Jiang Y, Xi H, Chen L, Feng X. Exploration of the Relationship Between Gut Microbiota and Polycystic Ovary Syndrome (PCOS): a Review. Geburtshilfe Frauenheilkd. 2020 Feb;80(2):161-171. doi: 10.1055/a-1081-2036. Epub 2020 Feb 21. PMID: 32109968; PMCID: PMC7035130.
  3.  Xue J, Li X, Liu P, Li K, Sha L, Yang X, Zhu L, Wang Z, Dong Y, Zhang L, Lei H, Zhang X, Dong X, Wang H. Inulin and metformin ameliorate polycystic ovary syndrome via anti-inflammation and modulating gut microbiota in mice. Endocr J. 2019 Oct 28;66(10):859-870. doi: 10.1507/endocrj.EJ18-0567. Epub 2019 Jul 3. PMID: 31270279.


Presented by April Lind, MD

April Lind is board-certified in Internal Medicine and Pediatrics. She has completed her Functional Medicine coursework with the Institute of Functional Medicine.  Dr. Lind is a certified Creighton FertilityCare Medical Consultant as well as a FEMM Medical Consultant. She practices primary care with a focus on women's health in Maple Grove, MN. She currently serves as past president on the IIRRM-A (International Institute for Restorative Reproductive Medicine of America) Board of Directors.

Additional references : 

Petriz BA, Castro AP, Almeida JA, Gomes CP, Fernandes GR, Kruger RH, Pereira RW, Franco OL. Exercise induction of gut microbiota modifications in obese, non-obese and hypertensive rats. BMC Genomics. 2014 Jun 21;15(1):511. doi: 10.1186/1471-2164-15-511. PMID: 24952588; PMCID: PMC4082611.

Lyte M, Vulchanova L, Brown DR. Stress at the intestinal surface: catecholamines and mucosa-bacteria interactions. Cell Tissue Res. 2011 Jan;343(1):23-32. doi: 10.1007/s00441-010-1050-0. Epub 2010 Oct 13. PMID: 20941511.

Balakrishnan M, Floch MH. Prebiotics, probiotics and digestive health. Curr Opin Clin Nutr Metab Care. 2012 Nov;15(6):580-5. doi: 10.1097/MCO.0b013e328359684f. PMID: 23037903.

Jakobsson HE, Jernberg C, Andersson AF, Sjölund-Karlsson M, Jansson JK, Engstrand L. Short-term antibiotic treatment has differing long-term impacts on the human throat and gut microbiome. PLoS One. 2010;5(3):e9836. Published 2010 Mar 24. doi:10.1371/journal.pone.0009836

Otles, Semih et. al. "Probiotics and Health". Asian Pacific Journal of Cancer Prevention, 4, 4, 2003, 369-372

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