Kuroda K et al.. "Novel approaches to the management of recurrent pregnancy loss: The OPTIMUM (OPtimization of Thyroid function, Thrombophilia, Immunity, and Uterine Milieu) treatment strategy".   This study aimed to determine if an “OPTIMUM” management strategy could improve pregnancy outcomes in women with a history of RPL. The strategy involved identifying and treating specific conditions such as chronic endometritis, elevated Th1/Th2 cell ratios, thyroid dysfunction, & thrombophilia when compared to a control group.