North American Virtual Conference for RRM 2020

Access to recordings and slides from this year’s North American Conference and Annual meeting for RRM are now available. Held on July 22, 2020 “virtually”, we are grateful to everyone—including the attendees, speakers, and facilitators—who made the conference a success. We heard from Amy Beckley, PhD, on the power of testing progesterone urine metabolites, Dr. Patrick Yeung on endometriosis adhesion prevention, and Dr. Joe Stanford on STORRM as well as a number of new RRM research abstracts. While we couldn’t meet physically we enjoyed the opportunity to see everyone virtually. Conference attendees receive free access to recordings and slides.

16th Annual General Meeting and International Conference for RRM

Recordings from IIRRM’s AGM and International Conference for RRM held in Dublin and Restorative Reproduction hosted by NeoFertility are now available for purchase. Updates in progesterone, DHEA and the Oestradiol curve, immunological aspects of infertility and reproductive health, treatment of silent endometriosis, an overview of the new Neo app and case studies as well as some surprising discoveries! Fill out the online evaluations for each day to receive up to 12 CME/CPD are available until Sept 27, 2019.

Latin American Conference For RRM

This 3 day conference brought together health care professionals from around the world to Santiago, Chile working with the common goal to improve, and discuss research and patient care in the field of Restorative Reproductive Medicine.  Hosted by Clinica Universidad de los Andes, and Sponsored by IIRRM the event offered professional development, education, networking and highlights of new research in the RRM field. Available presentations have live Spanish video and audio with a separate recorded audio-English translation.

RRM Bulletin: Vol. 8

Effects of medications on mucus
The fertility charts of women using fertility awareness based methods (FABMs) is a wonderful tool for seeing changes in life. Mucus quantity and quality, as well as days of mucus, can be seen to diminish with age, stress, weight loss, and strenuous exercise regimens. Dry cycles, or those with very limited mucus, can make it challenging to find optimal timing for days of fertility, and for lab testing or tracking when to start progesterone or other hormonal supplementation.

Journal Nook : April Edition

Recurrent miscarriage (RM), defined as two or more consecutive losses of clinical pregnancy, affects about 1-2% of women. Etiologies can include uterine abnormalities, antiphospholipid antibody, chromosomal abnormalities, thrombophilic disorders, infections, autoimmune disease, and endocrine disorders. However, about 50% of RM have unknown etiology, and immunological abnormalities are presumed to play a large role. Although there is controversy over the role of natural killer cells (NK) in infertility and RM, a recent systematic review showed …

Journal Nook

Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood
This study created a fair bit of buzz in the news and across social media in May suggesting hormone exposure in the womb may be a cause of PCOS, and a gonadotrophin-blocking treatment, cetrorelix, could be used to treat and prevent PCOS . New research from France suggests PCOS may develop in women who were exposed to elevated levels of AMH in-utero. They found pregnant women with PCOS had higher levels of AMH than normal. The elevated AMH seems to trigger a maternal neuroendocrine driven testosterone excess and decreases the placental metabolism of testosterone to estradiol, leading to masculinization of the exposed female fetus. Given PCOS tends to run in families, this explanation could make sense. In this study, pregnant mice were injected with the antimüllerian hormone (AMH), to mimic the hormonal imbalance they observed in the women with PCOS. Sure enough, after injection of the mothers, the next generation of female mice developed symptoms that are very similar to PCOS – such as elevated testosterone levels and disrupted ovulation. The team noted it is planning on looking at how hormones such as testosterone, regulated during pregnancy, affect their offspring.

Of course this study was done on mice, so we don’t yet know the same thing happens in women, and although we know gonadotrophin hormones are often raised in women with PCOS, blocking these hormones can help manage some symptoms but may not necessarily mean a cure. The drug suggested, which is commonly used in IVF, would prevent ovulation altogether so we don’t know the affect this would have on fertility.

RRM Bulletin : January 2019 Edition

Comprensive Health Assessments in RRM (CHARRM) : Polycystic Ovaries on Ultrasound – Criteria for diagnosing PCOS as outlined in the Rotterdam criteria and the Androgen Excess PCOS Society require the identification of polycystic ovaries. The most common way of doing this is by use of ultrasound. In hirsute women with normal menstruation, over 90% have polycystic ovaries on ultrasound. [1] Conversely, 20 – 30% of women also show evidence of multiple ovarian cysts. Specific diagnostic criteria thus are required to determine if patients truly have polycystic ovaries. This is often difficult information to ascertain from the write-ups provided by radiologists, unless they are asked specific morphologic questions.

The original criteria as outlined by the Rotterdam group were the presence of 12 or more follicles of 2 -9mm diameter and/or ovarian volume of 10cm 3 in one or both ovaries. Significant advances in imaging, particularly three-dimensional ultrasound, has resulted in some researchers proposing more advanced morphology to better identify these patients