May Journal Club: Dopamine, vascular permeability, and inflammation as relates to endometrium, pelvic pain, and pregnancy loss

Dr. Carpentier shares his experience with and looks into the science behind the use of dexamphetamine treatment as a novel off-label treatment for a number of female chronic disorders that do not respond well to conventional therapy including recurrent pregnancy loss, inflammation, and ongoing pain.    The primary article of focus for this journal club, “The neurotransmitter dopamine modulates vascular permeability in the endothelium”, along with a list of references can be downloaded to accompany the webinar.

March Journal Club: Sex Differences in Covid Severity

Men are consistently overrepresented in severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection, and coronavirus disease 2019 (COVID-19) severe outcomes, including higher fatality rates. This journal club examines a review that sought to summarize the available literature regarding proposed molecular and cellular markers of COVID-19 infection, their associations with health outcomes, and any reported modification by sex.

January Journal Club: A Simple and Improved Predictor of Insulin Resistance Extracted From the OGTT

This Journal club presented by Dr. Mary Davenport, looks at the article by Contreras P. et. al , “Simple and Improved Predictor of Insulin Resistance Extracted From the Oral Glucose Tolerance Test: The I0*G60”. Dr. Davenport is a FertilityCare Medical Consultant and a Fellow of the RHRI, with a master’s degree in nutrition and metabolism, which informs her integrative approach to women’s health care, and is a private practice OBGYN in the San Francisco, USA area.

October Journal Club: RCT of letrozole and clomiphene citrate or letrozole alone for ovulation induction in women with PCOS

Presented by Dr. Joseph Stanford. A randomized controlled trial of combination letrozole and clomiphene citrate or letrozole alone for ovulation induction in women with polycystic ovary syndrome. Does a combination of letrozole and clomiphene citrate result in higher ovulation rates than letrozole alone in infertile women with polycystic ovary syndrome (PCOS)?

September Journal Club : New Discovery Regarding the Doxycycline Molecule: Role for RRM Regarding Chronic Endometritis

Journal Club sessions provide a critical appraisal of published research relevant to the field of Restorative Reproductive Medicine. This presentations reviews the connection and potential use in RRM from the following two articles: Non-antibacterial tetracycline formulations: clinical applications in dentistry and medicine and Chronic endometritis due to common bacteria ….

April Journal Club: Treatment-independent live birth after in-vitro fertilisation: a retrospective cohort study of 2,133 women

Dr. Joseph Stanford reviews a study, published in Human Reproduction, which found 1 in 6 women to have an unassisted live birth after IVF. All women, who attended the Aberdeen Fertility Clinic and received IVF treatment between 1998 and 2011 (2133) were followed up followed over 5 years of follow-up, the treatment-independent live birth rate was 17% in unsuccessfully treated women and 15% in those who had a live birth after IVF.

March Journal Club: Pre-conception 25-hydroxyvitamin D (25(OH)D) and fecundability

This webinar discusses a community-based prospective cohort study on “Pre-conception 25-hydroxyvitamin D (25(OH)D) and fecundability”.  Journal Club sessions provide a critical appraisal of published research relevant to the field of Restorative Reproductive Medicine. These sessions are designed to increase providers’ competence to critically evaluate research by increasing their knowledge of the scientific method, research design, and common biases.