March Journal Club: Pre-conception 25-hydroxyvitamin D (25(OH)D) and fecundability

This webinar discusses a community-based prospective cohort study on “Pre-conception 25-hydroxyvitamin D (25(OH)D) and fecundability”.  Journal Club sessions provide a critical appraisal of published research relevant to the field of Restorative Reproductive Medicine. These sessions are designed to increase providers’ competence to critically evaluate research by increasing their knowledge of the scientific method, research design, and common biases.

November Journal Club: “A Randomized Trial of Progesterone in Women with bleeding in Early Pregnancy

Bleeding in early pregnancy is strongly associated with pregnancy loss. Progesterone is essential for the maintenance of pregnancy. Several small trials have suggested that progesterone therapy may improve pregnancy outcomes in women who have bleeding in early pregnancy. A multicenter, randomized, double-blind, placebo-controlled trial to evaluate progesterone, as compared with placebo, in women with vaginal bleeding in early pregnancy.

August Journal Club: Combined Letrozole and Clomiphene versus Letrozole and Clomiphene alone in infertile women with Poly Cystic Ovarian Syndrome

Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of childbearing age (6.8%–18%), is among the most common causes of infertility due to ovulation factors, and accounts for 55%–70% of infertility cases caused by chronic anovulation. In this study, we used a combination of letrozole and clomiphene in patients resistant to both drugs individually, and studied the effects of this combination in ovulation and pregnancy in resistant PCOS patients.

May Journal Club: Menstrual Preconditioning for the Prevention of Major Obstetrical Syndromes in Polycystic Ovarian Syndrome

Presented by Dr. Eddie Fleming. The presence of multiple ovarian cysts, anovulation, and endometrial progesterone resistance in the neonate seems remarkably similar to ovarian and endometrial features of the polycystic ovary syndrome (PCOS) of adolescent and adult women. Could cyclic administration of clomiphene citrate for a period to be determined by vascular response be an appropriate tool to reduce the risk of major obstetric syndromes by menstrual preconditioning?

Journal Club: The Effect of Maternal Obstructive Sleep Apnea on the Placenta

Obstructive sleep apnea (OSA) during pregnancy has been associated with adverse maternal outcomes. However, the effect of maternal OSA on fetal growth is less clear. This study aimed to investigate the effect of maternal OSA on placental growth and function. Dr. Lynn Keenan is a Professor of Clinical Medicine at UCSF and the program director of Sleep Medicine Fellowship. She also specializes in restorative approaches to women’s healthcare and the vice-president of IIIRRM.

Journal Club: Natural conception rates in subfertile couples following fertility awareness training

Sub-fertile couples who were taught about fertility awareness had a natural conception rate of 38% compared to 21.6% for those who were not after 8 months. This increased to increased to 56% after 1-2 years. Tentative conclusion of the study : “Training women to identify their fertile window in the menstrual cycle seems to be a reasonable first-line therapy in the management of subfertility.”  

Journal Club: The Effect of Intravenous immunoglobulin on Th1 and Th2 lymphocytes and improvement of pregnancy outcome in recurrent pregnancy loss

Women with elevated natural killer (NK) cell frequency and function during pregnancy, suffer from recurrent pregnancy loss (RPL). In the present study, the possible effect of intravenous immunoglobulin (IVIG) administration on Th1 and Th2 cell frequency, cytokine secretion, and expression of transcription factors is compared between RPL patients and control group. This article is explored in this months Journal Club.