January 2022 JC

January Journal Club: Unexplained recurrent pregnancy loss and unexplained infertility

“Is B-cell CLL/lymphoma 6 (BCL6) endometrial expression, a surrogate biomarker of endometriosis, elevated in women with unexplained recurrent pregnancy loss (uRPL) and unexplained infertility (UI) compared to fertile subjects?”. What could this study suggest for potential treatment and future investigations for recurrent miscarriage and unexplained pregnancy loss? Review the findings of this study in the IIRRM Journal club with Dr. Joe Stanford.

Journal Club: Reproductive life in women with celiac disease

Review the findings with Dr Joseph Stanford, of a population-based cohort study examining the impact of celiac disease on women’s reproductive health from Grode et. al.1 in October’s Journal club. “How does celiac disease (CD) influence women’s reproductive life, both prior to and after the diagnosis?” – Download the article before viewing the webinar.

May Journal Club: Dopamine, vascular permeability, and inflammation as relates to endometrium, pelvic pain, and pregnancy loss

Dr. Carpentier shares his experience with and looks into the science behind the use of dexamphetamine treatment as a novel off-label treatment for a number of female chronic disorders that do not respond well to conventional therapy including recurrent pregnancy loss, inflammation, and ongoing pain.    The primary article of focus for this journal club, “The neurotransmitter dopamine modulates vascular permeability in the endothelium”, along with a list of references can be downloaded to accompany the webinar.

March Journal Club: Sex Differences in Covid Severity

Men are consistently overrepresented in severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection, and coronavirus disease 2019 (COVID-19) severe outcomes, including higher fatality rates. This journal club examines a review that sought to summarize the available literature regarding proposed molecular and cellular markers of COVID-19 infection, their associations with health outcomes, and any reported modification by sex.

January Journal Club: A Simple and Improved Predictor of Insulin Resistance Extracted From the OGTT

This Journal club presented by Dr. Mary Davenport, looks at the article by Contreras P. et. al , “Simple and Improved Predictor of Insulin Resistance Extracted From the Oral Glucose Tolerance Test: The I0*G60”. Dr. Davenport is a FertilityCare Medical Consultant and a Fellow of the RHRI, with a master’s degree in nutrition and metabolism, which informs her integrative approach to women’s health care, and is a private practice OBGYN in the San Francisco, USA area.

October Journal Club: RCT of letrozole and clomiphene citrate or letrozole alone for ovulation induction in women with PCOS

Presented by Dr. Joseph Stanford. A randomized controlled trial of combination letrozole and clomiphene citrate or letrozole alone for ovulation induction in women with polycystic ovary syndrome. Does a combination of letrozole and clomiphene citrate result in higher ovulation rates than letrozole alone in infertile women with polycystic ovary syndrome (PCOS)?