November Journal Club: “A Randomized Trial of Progesterone in Women with bleeding in Early Pregnancy

Bleeding in early pregnancy is strongly associated with pregnancy loss. Progesterone is essential for the maintenance of pregnancy. Several small trials have suggested that progesterone therapy may improve pregnancy outcomes in women who have bleeding in early pregnancy. A multicenter, randomized, double-blind, placebo-controlled trial to evaluate progesterone, as compared with placebo, in women with vaginal bleeding in early pregnancy.

Journal Club: Luteal Start Vaginal Micronized Progesterone Improves Pregnancy Success in Women with Recurrent Pregnancy Loss

Presented by Dr. Joseph Stanford Referenced Article: Luteal start vaginal micronized progesterone improves pregnancy success in women with recurrent pregnancy loss. Stephenson, Mary D. et al.  Fertility and Sterility, Volume 107, Issue 3, 684 – 690.e2 Download the article Objective To assess the effectiveness of luteal start vaginal micronized P in a recurrent pregnancy loss (RPL) cohort. Design Observational cohort study using prospectively collected data. Setting Not applicable. Patient(s) Women seen between 2004 and 2012 with a history of two or more unexplained pregnancy losses <10 weeks in size; endometrial biopsy (EB) performed 9–11 days after LH surge; and one or more subsequent pregnancy(ies). […]

Journal Club: Progesterone in Women with Recurrent Miscarriages

A Randomized Trial of Progesterone in Women with Recurrent Miscarriages January Journal Club with Dr. Paul Carpentier REF Article: Coomarasamy, Arri & Williams, Helen & Truchanowicz, Ewa & Seed, Paul & Small, Rachel & Quenby, Siobhan & Gupta, Pratima & Dawood, Feroza & Koot, Y & Bender Atik, Ruth & Bloemenkamp, Kitty & Brady, Rebecca & Briley, Annette & Cavallaro, Rebecca & Cheong, Ying & J Chu, Justin & Eapen, Abey & Ewies, Ayman & Hoek, Annemieke & Rai, Rajendra. (2015). A Randomized Trial of Progesterone in Women with Recurrent Miscarriages. The New England journal of medicine. 373. 2141-2148. 10.1056/NEJMoa1504927.  […]