October RRM Journal Club

Presented by: Joseph Stanford, MD, MSPH.


Does a combination of letrozole and clomiphene citrate result in higher ovulation rates than letrozole alone in infertile women with polycystic ovary syndrome (PCOS)?



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Ref: Mejia RB, Summers KM, Kresowik JD, Van Voorhis BJ. A randomized controlled trial of combination letrozole and clomiphene citrate or letrozole alone for ovulation induction in women with polycystic ovary syndrome. Fertil Steril. 2019;111(3):571-578.e1. doi:10.1016/j.fertnstert.2018.11.030

Continuing Medical Education Accreditation and Credit Statement:

IIRRM Journal Club Learning Outcomes:

  • locate, appraise, and assimilate evidence in scientific studies related to Restorative Reproductive Medicine
  • evaluate the hypothesis, the study design, the method and the results in a systematic fashion.
  • apply knowledge learned in journal clubs, of study designs and statistical methods, to the appraisal of clinical studies and other information on diagnostic and therapeutic effectiveness
  • determine the clinical applicability of a particular study to RRM practice
  • apply this knowledge to improve knowledge, competency, performance, and patient outcomes in RRM
  • identify gaps in the field of RRM and opportunities for future research


IIRRM asks all individuals, involved in the development and presentation of Continuing Medical Education (CME) activities to disclose all relevant financial relationships with commercial interests. This information is disclosed to CME activity participants prior to the start of the educational activity. IIRRM has procedures to resolve all conflicts of interest. In addition, faculty members are asked to disclose when any unapproved use of pharmaceuticals and devices is being discussed.

Discussion of unapproved or investigational uses of products or devices:

This presentation includes a discussion on letrozole for use in ovulation induction.  While this use is not yet FDA-approved, it is widely supported by many peer-reviewd articles in the medical literature, which include randomized trials.

Joseph Stanford, MD, MSPH

Presenter, IIRRM Medical Director of CME Activities
Director of the Office of Cooperative Reproductive Health
Professor in the Department of Family Preventive Medicine
University of Utah, Utah, USA.
Faculty member has nothing to disclose with regards to commercial support.