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Grand Rounds: Role of Vitamin D in Women’s Reproductive Health

27 October 2022 8:00 PM - 9:00 PM
Application for CME credit has been filed with the American Academy of Family Physicians. Determination of credit is pending.


Presented by Anne Marie Z. Jukic, Ph.D., this presentation will synthesize her research on the role of vitamin D and reproductive health, including on the menstrual cycle, time to pregnancy, ovarian reserve, and inflammation.


Learning outcomes: 

  • Describe and understand vitamin D metabolism
  • Review animal studies related to vitamin D and fertility and how the information gained may be used to further understand human reproductive health.
  • Describe current human studies of vitamin D in menstrual cycles and fertility
  • Understand the potential biological pathways that might underlie the associations in these studies



Dr. Anne Marie Jukic is the principal investigator and head of the Fertility and Reproductive Health Group at the National Institute of Environmental Health Sciences (NIEHS/NIH).  The Fertility and Reproductive Health Group focuses on factors that influence reproductive function (e.g., follicle development and menstrual cycles), conception, implantation, placental development, and pregnancy outcomes.

See research & work at NIEHS.

Anne Marie Jukic, PhD.

Anne Marie Jukic, PhD.

Principal Investigator.

Dr.  Jukic has published observational trials and early studies, associating lower vitamin D levels with increased risk of abnormal menstrual cycles and impaired fertility in women1-7, and is currently recruiting for a clinical trial to investigate further the role of vitamin D, the menstrual cycles and menstrual cycle hormones.  The trial is still currently recruiting patients. A website for patients is also available here.  Please note that patients will need to visit the Henry Ford Center, located in Detroit, MI, USA, to participate.

Other areas of ongoing research with the NIEHS include the correlations between vitamin D and metals levels, air pollution, fertility and pregnancy loss, microRNA in early pregnancy, and methodological challenges in reproductive epidemiology.

Dr. Anne Marie Jukic received a B.S. from the University of Notre Dame, an M.S.P.H. from Emory University, and a Ph.D. in epidemiology from the University of North Carolina at Chapel Hill. She completed a postdoctoral fellowship at NIEHS and was an Assistant Professor at the Yale School of Public Health before joining NIEHS.

Dr. Jukic has published a number of publications looking at factors that influence reproductive function, health and fertility.




1Jukic AM, Steiner AZ, Baird DD. Lower plasma 25-hydroxyvitamin D is associated with irregular menstrual cycles in a cross-sectional study. Reprod Biol Endocrinol. 2015;13:20. Published 2015 Mar 11. doi:10.1186/s12958-015-0012-5

2Jukic AMZ, Upson K, Harmon QE, Baird DD. Increasing serum 25-hydroxyvitamin D is associated with reduced odds of long menstrual cycles in a cross-sectional study of African American women. Fertil Steril. 2016;106(1):172-179.e2. doi:10.1016/j.fertnstert.2016.03.004

3Jukic AMZ, Wilcox AJ, McConnaughey DR, Weinberg CR, Steiner AZ. 25-Hydroxyvitamin D and Long Menstrual Cycles in a Prospective Cohort Study. Epidemiology. 2018;29(3):388-396. doi:10.1097/EDE.0000000000000804

4Jukic AMZ, Zuchniak A, Qamar H, Ahmed T, Mahmud AA, Roth DE. Vitamin D Treatment during Pregnancy and Maternal and Neonatal Cord Blood Metal Concentrations at Delivery: Results of a Randomized Controlled Trial in Bangladesh. Environ Health Perspect. 2020;128(11):117007. doi:10.1289/EHP7265

5Jukic AMZ, Kim SS, Meeker JD, et al. A prospective study of maternal 25-hydroxyvitamin D (25OHD) in the first trimester of pregnancy and second trimester heavy metal levels. Environ Res. 2021;199:111351. doi:10.1016/j.envres.2021.111351

6A Subramanian, A Z Steiner, C R Weinberg, G L Doss, A M Z Jukic, Preconception vitamin D and miscarriage in a prospective cohort study, Human Reproduction, 2022;, deac155, doi:/10.1093/humrep/deac155

7Jukic AMZ, Harmon QE. Accumulating evidence for vitamin D and conception. Fertil Steril. 2020;113(2):330-331. doi:doi:/10.1093/humrep/deac155

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October 27
8:00 PM - 9:00 PM BST
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Anne Marie Jukic, PhD, MSPH.
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