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May Journal Club: Dopamine, vascular permeability, and inflammation as relates to endometrium, pelvic pain, and pregnancy loss

May 11 @ 8:00 PM - 9:00 PM BST

Virtual Virtual Webinar

Exploring the basic science underlying Dr. Jerome Check's insights into dexamphetamine treatment for recurrent pregnancy loss, inflammation, and ongoing pain.

Presented by: Paul Carpentier, MD, CFCMC.

Dr. Paul Carpentier discusses the science behind the use of dexamphetamine treatment for recurrent pregnancy loss, inflammation, and ongoing pain.  The primary article of focus for this journal club "The neurotransmitter dopamine modulates vascular permeability in the endothelium" can be downloaded ahead of the webinar.  Additional articles will be references during this presentation and are listed below.

Interested in learning more about this topic and Check's work before the webinar? Dr. Jerome Check presented at our international conference in Dublin, Ireland along with some case studies from Dr. Boyle.  Presentations and slides are available for free member's viewing and download here.  Non-Members can also purchase on-demand access here.   For those that missed our November 2-day virtual conference, Dr. Jerome Check looked at novel approaches to infertility including the use of dexamphetamine.  Complete access to this conference is still available for purchase to watch on-demand.

Journal Club sessions provide a critical appraisal of published research relevant to the field of Restorative Reproductive Medicine. These sessions are designed to increase providers’ competence to critically evaluate research by increasing their knowledge of the scientific method, research design, and common biases. Improvements in knowledge and competence will translate into improvements in clinician performance as they use their understanding of research to provide better care and communication to their patients and apply the results from research to clinical practice.

Approved for 1.0 Live, virtual CME prescribed credit*. For more information about how this can be reported and submitted to other organizations please see the AAFP website here.

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Webinars are free for all IIRRM members.

Not a member?  Join or renew your membership here.

Paul Carpentier is a family physician, now specializing in women’s healthcare, recently teamed with Catholic Health Services of Long Island to successfully open the latest Gianna Center for Women’s Health and Fertility and currently serves as its medical director. This highly regarded Center attends to women of all ages, especially those with various reproductive health issues and men with infertility, and helps to train family medicine and obstetrical residents, gynecology fellows, and women’s health nurse practitioners in restorative reproductive medicine and surgery.

Formerly president of In His Image Family Medicine in Massachusetts, his practice contributed data to the international NaProTECHNOLOGY Effectiveness Study (iNEST) and has submitted for publication a twenty-five-year retrospective clinical study of NaProTECHNOLOGY for the treatment of infertility.  He was one of the first family physicians trained in NaProTECHNOLOGY and was honored with the international AAFCP award for Outstanding Medical Consultant in Natural Family Planning.  He was a recent president of The American Academy of FertilityCare Professionals, and he currently serves on the Healthcare Policy Committee of the Catholic Medical Association in the USA as well as on the Board of Directors for the IIRRM.  He is a graduate of St. Louis University School of Medicine with honors in High-Risk Obstetrics and Medical Ethics, he and his wife Suzanne are parents to four professional young men.

References:

  1.  Bhattacharya R, Sinha S, Yang SP, et al. The neurotransmitter dopamine modulates vascular permeability in the endothelium. J Mol Signal. 2008;3:14. Published 2008 Jul 28. doi:10.1186/1750-2187-3-14
  2. Vidal PM, Pacheco R. Targeting the Dopaminergic System in Autoimmunity. J Neuroimmune Pharmacol
    2020 Mar;15(1):57-73. doi: 10.1007/s11481-019-09834-5. Epub 2019 Jan 19. PMID: 30661214.
  3. Developmental Cell, Volume 16, Issue 2, 209 - 221. doi: 10.1016/j.devcel.2009.01.004
  4. Dvorak HF. Vascular permeability to plasma, plasma proteins, and cells: an update. Curr Opin Hematol.
    2010;17(3):225-229. doi:10.1097/MOH.0b013e3283386638.
  5. Huybrechts, Krista F et al. Association Between Methylphenidate and Amphetamine Use in Pregnancy and Risk of Congenital Malformations: A Cohort Study From the International Pregnancy Safety Study Consortium.”JAMA psychiatry vol. 75,2 (2018): 167-175. doi:10.1001/jamapsychiatry.2017.3644
  6. Cooper WO. Shedding Light on the Risks of Methylphenidate and Amphetamine in Pregnancy. JAMA Psychiatry. 2018 Feb 1;75(2):127-128. doi: 10.1001/jamapsychiatry.2017.3882. PMID: 29238801.
  7. Ancelin M, Buteau-Lozano H, Meduri G, et al. A dynamic shift of VEGF isoforms with a transient and selective progesterone-induced expression of VEGF189 regulates angiogenesis and vascular permeability in human uterus.  Proc Natl Acad Sci U S A. 2002;99(9):6023-6028. doi:10.1073/pnas.082110999.
  8. Goddard LM, Murphy TJ, Org T, et al. Progesterone receptor in the vascular endothelium triggers physiological uterine permeability preimplantation. Cell. 2014;156(3):549-562.  doi:10.1016/j.cell.2013.12.025.
  9. Check, J. (2015). Sympathomimetic amines are a safe, highly effective therapy for several female chronic disorders that do not respond well to conventional therapy. Clinical and experimental obstetrics & gynecology. 42. 267-78. 10.12891/ccog3089.2015. Accessed April 2021: https://ccivf.com/files/2019/05/717.pdf.
  10. Check JH, Katsoff D, Kaplan H, Liss J, Boimel P. A disorder of sympathomimetic amines leading to increased vascular permeability may be the etiologic factor in various treatment-refractory health problems in women. Med Hypotheses. 2008;70(3):671-7. doi: 10.1016/j.mehy.2007.05.052. Epub 2007 Aug 31. PMID: 17765403.
  11. Check. JH. Sympathomimetic Treatment – Original Concept, Clinical Experience, Wide Range of Conditions.  International Institute of Restorative Reproductive Medicine Annual General Meeting. Dublin, Ireland. September 6, 2019.
  12. Check JH, Check DL, Cohen R. ASRM, October 2019, Philadelphia.  Sympathomimetic amine therapy may improve live delivered pregnancy
    rates following IVF-ET in women of advanced reproductive age – a pilot study.
  13. Matt SM, Gaskill PJ. Where Is Dopamine and how do Immune Cells See it?: Dopamine-Mediated Immune Cell Function in Health and Disease. J Neuroimmune Pharmacol. 2020 Mar;15(1):114-164. doi: 10.1007/s11481-019-09851-4. Epub 2019 May 11. PMID: 31077015; PMCID: PMC6842680.

IIRRM Journal Club Learning Outcomes:

  • locate, appraise, and assimilate evidence in scientific studies related to Restorative Reproductive Medicine
  • evaluate the hypothesis, the study design, the method, and the results in a systematic fashion.
  • apply knowledge learned in journal clubs, of study designs and statistical methods, to the appraisal of clinical studies and other information on diagnostic and therapeutic effectiveness
  • determine the clinical applicability of a particular study to RRM practice
  • apply this knowledge to improve knowledge, competency, performance, and patient outcomes in RRM
  • identify gaps in the field of RRM and opportunities for future research

Disclosures

IIRRM asks all individuals, involved in the development and presentation of Continuing Medical Education (CME) activities to disclose all relevant financial relationships with commercial interests. This information is disclosed to CME activity participants prior to the start of the educational activity. IIRRM has procedures to resolve all conflicts of interest. In addition, faculty members are asked to disclose when any unapproved use of pharmaceuticals and devices is being discussed.

Off-Label Discussion

This activity includes the discussion of off-label use of dextroamphetamine sulfate to treat a number of women's health conditions dysmenorrhea, infertility, and miscarriage.  Dextroamphetamine sulfate has been FDA approved for the treatment and management of Attention Deficit Hyperactivity Disorder (ADHD) and narcolepsy but is not currently approved for the conditions discussed in this activity.

 

Continuing Medical Education Accreditation and Credit Statement:

*The AAFP has reviewed May Journal Club and deemed it acceptable for AAFP credit. Term of approval is from May 11th 2021 to May 11th 2021.

  • 1.00 Online Only, Live AAFP Prescribed Credit(s) - May Journal Club

AAFP Prescribed credit is accepted by the American Medical Association as equivalent to AMA PRA Category 1 Credit™ toward the AMA Physician's Recognition Award. When applying for the AMA PRA, Prescribed credit earned must be reported as Prescribed credit, not as Category 1.

Members of the College of Family Physicians of Canada are eligible to receive 1.0  Certified or Non-Certified Mainpro+ credits for participation in this activity due to reciprocal agreement with the American Academy of Family Physicians.

The Qatar Council for Health Practitioners (QCHP) accepts American Academy of Family Physicians (AAFP) Prescribed credit as equivalent to Category 1 – Accredited Group Learning Activities and Category 3 – Accredited Assessment Activities. When reporting AAFP Prescribed credit to the QCHP, AAFP Prescribed credit earned must be reported as AAFP Prescribed Credit equivalent to Category (1 or 3).

AAFP Prescribed credit is accepted by the following organizations. Please contact them directly about how participants should report the credit they earned.

  • American Academy of Physician Assistants (AAPA)
  • National Commission on Certification of Physician Assistants (NCCPA)
  • American Nurses Credentialing Center (ANCC)
  • American Academy of Nurse Practitioners Certification Board (AANPCB)
  • American Association of Medical Assistants (AAMA)
  • American Board of Family Medicine (ABFM)
  • American Board of Emergency Medicine (ABEM)
  • American Board of Preventative Medicine (ABPM)
  • American Board of Urology (ABU)

Webinar recordings and slides are posted to iirrm.org for those that can't attend, however AAFP Prescribed Credit and AMA PRA Category 1 credits are only available for lecture webcasts viewed live, in real time.

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Date:
May 11
Time:
8:00 PM - 9:00 PM BST
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