March Journal Club: Lisinopril for Male Infertility: An Update and Mechanism of Action
IIRRM Journal Club sessions provide a critical appraisal of published research relevant to the field of Restorative Reproductive Medicine. Sessions are designed to increase providers’ competence to critically evaluate research by increasing their knowledge of the scientific method, research design, and common biases.
The following articles will be referenced in this discussion, and are available for download below:
- Pan, Pei-Pei et al. “Angiotensin-converting enzymes play a dominant role in fertility.” International journal of molecular sciences vol. 14,10 21071-86. 21 Oct. 2013, doi:10.3390/ijms141021071
Biochemistry background of ACEs in Male Fertility:
- Mbah, A U et al. “Low-dose lisinopril in normotensive men with idiopathic oligospermia and infertility: a 5-year randomized, controlled, crossover pilot study.” Clinical pharmacology and therapeutics vol. 91,4 (2012): 582-9. doi:10.1038/clpt.2011.265
- Bernstein KE, Ong FS, Blackwell WL, et al. "A modern understanding of the traditional and nontraditional biological functions of angiotensin-converting enzyme" [published correction appears in Pharmacol Rev. 2013;65(1):544]. Pharmacological reviews. vol. 65,1 1-46. 20 Dec. 2012, doi:10.1124/pr.112.006809
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Additionally, download a note-taking sheet with question prompts to consider when evaluating medical research here.
Approved for 1.0 Online Only, Live AAFP Prescribed Credit*
Presented by: Paul Carpentier, MD, CFCMC.
Dr. Carpentier specializes in women’s healthcare, and teamed with Catholic Health to successfully open the Long Island Gianna Center for Women’s Health and Fertility and served as its first medical director. This highly regarded Center attends women of all ages, especially those with various reproductive health issues and men with infertility, and helps to train family medicine residents and others in restorative reproductive medicine and surgery.
Dr. Carpentier is a graduate of St. Louis University School of Medicine with honours in High Risk Obstetrics and Medical Ethics, and serves on the board of trustees of IIRRM. He and his wife Suzanne are proud parents to four professional young men.
Continuing Medical Education Accreditation and Credit Statement: