Dr. Chang is board certified in reproductive endocrinologist and Obstetrics and Gynecology at Cooper Medical School of Rowan University. As an alumnus from The University of Osteopathic of Medicine, in Des Moines, IA, in 2002, Dr. Chang has completed a Reproductive Endocrinology and Infertility fellowship with Drs. Check and Choe in 2018 and is presently one of Dr. Check’s associates. He has presented some of his data at the 2017 meeting of the American Society for Reproductive Medicine.
Dr. Chang presents on “The efficacy of endometrial irritation and mid-luteal phase injection of GnRH agonist to improve fecundity” with the following learning outcomes:
1. To familiarize the audience with the importance of inadequate uterine remodeling as a potential cause of unexplained infertility and implantation defects.
2. To familiarize the audience with the importance of the cellular immune system in the creation of spiral arterioles to allow nutrient exchange between mother and fetus.
3. To familiarize the audience in some methods used by the fetal-placental unit to counteract this increased cellular immune response from immune attack of the fetal semi-allograft.
4. To familiarize the audience with the possible role of endometrial irritation (scratch) in improving potential inadequate uterine re-modeling related to an inadequate cellular immune response.
5. To make the audience aware that the endometrial scratch can be a double-edged sword in that in some circumstances it can produce an excessive cellular immune response thus inhibiting successful implantation.
6. The objective is to present some data suggesting when to employ the endometrial scratch and when not to use it.
7. The objective is to learn when in the menstrual cycle is the best time to perform the procedure.
8. The objective is to suggest how long the effectiveness of the endometrial scratch is.
In addition Dr. Chang is a co-author of the following publications.
1. Check JH, Aly J, Chang E: Improving the chance of successful implantation – part I – embryo attachment to the endometrium and adequate trophoblast invasion. Clin Exp Obst Gynecol 2016;43:787-791.
2. Check JH, Chern R, Chang E: Successful pregnancy following in vitro fertilization-embryo transfer in a woman with diminished oocyte reserve despite a slow rising beta human chorionic gonadotropin level. Clin Exp Obst Gyn 2017;44:509-510.
3. Check JH, Chang E: No evidence to support the concept that endometrial polyps impair fertility in the majority of cases. Clin Exp Obst Gyn 2018;45:159-162.
He is a co-author or first author of the following published abstracts:
1. Check JH, Choe JK, Cohen R, Chang E, Wilson W: Pregnancy outcome following fresh vs. frozen embryo transfer on embryos created with the serum progesterone >2 ng/mL on the day of the human chorionic gonadotropin trigger in women with decreased egg reserve. American Society for Reproductive Medicine, Salt Lake City, UT, October 15-19, 2016. Fertil Steril 2016;106:e339-340.
2. Chang E, Check JH, Liss JR, Choe J, Cohen R: An endometrial scratch can improve pregnancy rates in natural cycles of women with unexplained infertility given luteal phase support. Fertil Steril 2017;108:e369, P-687.
3. Check JH, Cohen R, Chang E: Inhibiting mitochondrial permeability by treating with sympathomimetic amines may reverse the adverse effect of age and diminished egg reserve on fecundity. Proceedings from the American Association for Clinical Endocrinologists 27th Annual Scientific & Clinical Congress, Boston, MA, May 16-20, 2018. Endo Pract 2018;24:208, abstract #902.
4. Cohen R, Check JH, Wilson C, Chang E, Choe J: Serum follicle stimulating hormone vs. anti-mullerian hormone levels as a prognosticating factor for success following in vitro fertilization in women with diminished oocyte reserve. Proceedings from the American Association for Clinical Endocrinologists 27th Annual Scientific & Clinical Congress, Boston, MA, May 16-20, 2018. Endo Pract 2018;24:212, abstract #909.
5. Cohen R, Check JH, Chang E, Greenblatt M, Vaniver J: Insight into the mechanism of the evoluation and subsequent regression of a follicular cyst secreting high levels of estradiol. Proceedings from the American Association for Clinical Endocrinologists 27th Annual Scientific & Clinical Congress, Boston, MA, May 16-20, 2018. Endo Pract 2018;24:212, abstract #910.
6. DiAntonio A, Check JH, Cohen R, Choe JK, Chang E: The first reported case of 2 successful pregnancies following follicle maturation by FSH down-regulation with ethinyl estradiol followed by in vitro fertilization of single oocytes in a woman with premature menopause. Proceedings from the American Association for Clinical Endocrinologists 27th Annual Scientific & Clinical Congress, Boston, MA, May 16-20, 2018. Endo Pract 2018;24:213-214, abstract #912. He has submitted 3 abstracts concerning his work on the endometrial scratch as part of his thesis for his REI fellowship.