Manipulating the cellular immune environment of the post-ovulatory endometrium to improve fecundity in natural cycles

Presented by: Eric Chang, DO  & Rachel Cohen, DO

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Learning Outcomes: 

1. To familiarize the audience with the importance of inadequate uterine remodeling as a potential cause of unexplained infertility and implantation defects.

2. To familiarize the audience with the importance of the cellular immune system in the creation of spiral arterioles to allow nutrient exchange between mother and fetus.

3. To familiarize the audience in some methods used by the fetal-placental unit to counteract this increased cellular immune response from immune attack of the fetal semi-allograft.

4. To familiarize the audience with the possible role of endometrial irritation (scratch) in improving potential inadequate uterine re-modeling related to an inadequate cellular immune response.

5. To make the audience aware that the endometrial scratch can be a double-edged sword in that in some circumstances it can produce an excessive cellular immune response thus inhibiting successful implantation.

6. The objective is to present some data suggesting when to employ the endometrial scratch and when not to use it.

7. The objective is to learn when in the menstrual cycle is the best time to perform the procedure.

8. The objective is to suggest how long the effectiveness of the endometrial scratch is.



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